[HTML][HTML] Recommendations for the effective use of T-cell–redirecting therapies: A Canadian consensus statement

G Lancman, K Song, D White, T Crosbie… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Background T-cell–redirecting therapies, such as bispecific antibodies and chimeric antigen
receptor T-cells, exploit the cytotoxic capabilities of the immune system to destroy cells …

Endothelial injury and dysfunction with emerging immunotherapies in multiple myeloma, the impact of COVID-19, and endothelial protection with a focus on the …

CC Mo, E Richardson, E Calabretta, F Corrado… - Blood Reviews, 2024 - Elsevier
Patients with multiple myeloma (MM) were among the groups impacted more severely by the
COVID-19 pandemic, with higher rates of severe disease and COVID-19-related mortality …

Patterns of CRS with teclistamab in relapsed/refractory multiple myeloma with or without prior T-cell redirection therapy

IS Hamadeh, T Shekarkhand, C Rueda, RS Firestone… - Blood Advances, 2024 - Elsevier
Teclistamab (Tec) is a first-in-class BCMA X CD3 bispecific T-cell engager antibody
approved for treating multiple myeloma progressing after at least 4 lines of therapy. The …

Bispecific antibodies for the treatment of relapsed/refractory multiple myeloma: updates and future perspectives

RD Parrondo, S Ailawadhi, C Cerchione - Frontiers in Oncology, 2024 - frontiersin.org
Patients with relapsed/refractory multiple myeloma (RRMM) that are refractory to the five
most active anti-MM drugs, so-called penta-refractory MM, have historically had dismal …

Bispecific antibody targets and therapies in multiple myeloma

M Rees, N Abdallah, B Yohannan… - Frontiers in …, 2024 - frontiersin.org
Recently, several bispecific antibodies (BsAbs) have been approved for the treatment of
relapsed multiple myeloma (MM) after early phase trials in heavily pre-treated patients …

The Challenging Approach to Multiple Myeloma: From Disease Diagnosis and Monitoring to Complications Management

S Morè, L Corvatta, VM Manieri, E Morsia, M Offidani - Cancers, 2024 - mdpi.com
Simple Summary Multiple myeloma (MM) represents the second most common
hematological malignancy, but its diagnosis can be significantly delayed since symptoms …

Practical insights into bispecific antibody therapy in multiple myeloma

Y Kawasaki, S Winger, N Esteghamat… - Expert Review of …, 2024 - Taylor & Francis
Introduction The rise of recent novel therapies teclistamab, elranatamab, and talquetamab
for the treatment of relapsed/refractory multiple myeloma (RRMM) is a rapidly evolving area …

International Myeloma Working Group immunotherapy committee consensus guidelines and recommendations for optimal use of T-cell-engaging bispecific antibodies …

P Rodriguez-Otero, S Usmani, AD Cohen… - The Lancet …, 2024 - thelancet.com
Multiple myeloma remains an incurable disease, despite the development of numerous drug
classes and combinations that have contributed to improved overall survival …

Engaging a New Treatment Paradigm: Elranatamab in Relapsed/Refractory Multiple Myeloma

G Saied, Z Halford - Annals of Pharmacotherapy, 2024 - journals.sagepub.com
Objective: To review the therapeutic profile of elranatamab, a novel bispecific T-cell-
redirecting therapy, in treating relapsed or refractory (R/R) multiple myeloma (MM). Data …

[HTML][HTML] Bispecific Antibodies for Multiple Myeloma: Recent Advancements and Strategies for Increasing Their Efficacy

M Wang, C Wang, J Deng, H Wang, C Sun… - Frontiers in Bioscience …, 2024 - imrpress.com
The treatment options for multiple myeloma (MM) have undergone significant transformation
with the advent of immunotherapy. Novel therapies that focus on tumor antigens now drive …