Abnormal tremors are the most common of all movement disorders. In this review we focus on the role of the cerebellum in Essential Tremor, a highly debilitating but poorly treated …
W Kakegawa, N Mitakidis, E Miura, M Abe, K Matsuda… - Neuron, 2015 - cell.com
Neuronal networks are dynamically modified by selective synapse pruning during development and adulthood. However, how certain connections win the competition with …
Structural changes in Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms that underlie these changes remain poorly understood. Climbing …
Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular …
LB Hills, A Masri, K Konno, W Kakegawa, ATN Lam… - Neurology, 2013 - AAN Enterprises
Objective: To identify the genetic cause of a syndrome causing cerebellar ataxia and eye movement abnormalities. Methods: We identified 2 families with cerebellar ataxia, eye …
Abstract Changes in climbing fiber-Purkinje cell (CF-PC) synaptic connections have been found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor …
M Yamasaki, T Miyazaki, H Azechi, M Abe… - Journal of …, 2011 - Soc Neuroscience
The number of synaptic AMPA receptors (AMPARs) is the major determinant of synaptic strength and is differently regulated in input pathway-dependent and target cell type …
M Beraneck, JL McKee, M Aleisa… - Journal of …, 2008 - journals.physiology.org
The term “vestibular compensation” refers to the resolution of motor deficits resulting from a peripheral vestibular lesion. We investigated the role of the cerebellum in the compensation …