Acute cerebellar inflammation and related ataxia: mechanisms and pathophysiology

MSA Parvez, G Ohtsuki - Brain sciences, 2022 - mdpi.com
The cerebellum governs motor coordination and motor learning. Infection with external
microorganisms, such as viruses, bacteria, and fungi, induces the release and production of …

Essential tremor–a cerebellar driven disorder?

MF Ibrahim, JC Beevis, RM Empson - Neuroscience, 2021 - Elsevier
Abnormal tremors are the most common of all movement disorders. In this review we focus
on the role of the cerebellum in Essential Tremor, a highly debilitating but poorly treated …

Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum

W Kakegawa, N Mitakidis, E Miura, M Abe, K Matsuda… - Neuron, 2015 - cell.com
Neuronal networks are dynamically modified by selective synapse pruning during
development and adulthood. However, how certain connections win the competition with …

Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum

CY Lin, ED Louis, PL Faust, AH Koeppen… - Brain, 2014 - academic.oup.com
Structural changes in Purkinje cells have been identified in the essential tremor cerebellum,
although the mechanisms that underlie these changes remain poorly understood. Climbing …

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners

SI Fraley, Y Feng, A Giri, GD Longmore… - Nature communications, 2012 - nature.com
Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge,
periodic cell migratory patterns have not been observed. Here we report the highly regular …

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans

LB Hills, A Masri, K Konno, W Kakegawa, ATN Lam… - Neurology, 2013 - AAN Enterprises
Objective: To identify the genetic cause of a syndrome causing cerebellar ataxia and eye
movement abnormalities. Methods: We identified 2 families with cerebellar ataxia, eye …

Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases

SH Kuo, CY Lin, J Wang, PA Sims, MK Pan, J Liou… - Acta …, 2017 - Springer
Abstract Changes in climbing fiber-Purkinje cell (CF-PC) synaptic connections have been
found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor …

Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome

G Berridge, DA Menassa, T Moloney, PJ Waters… - Neurology, 2018 - AAN Enterprises
Objective To identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome
(OMAS) using contemporary antigen discovery methodology. Methods OMAS patient serum …

Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells

M Yamasaki, T Miyazaki, H Azechi, M Abe… - Journal of …, 2011 - Soc Neuroscience
The number of synaptic AMPA receptors (AMPARs) is the major determinant of synaptic
strength and is differently regulated in input pathway-dependent and target cell type …

Asymmetric recovery in cerebellar-deficient mice following unilateral labyrinthectomy

M Beraneck, JL McKee, M Aleisa… - Journal of …, 2008 - journals.physiology.org
The term “vestibular compensation” refers to the resolution of motor deficits resulting from a
peripheral vestibular lesion. We investigated the role of the cerebellum in the compensation …