Since an immunoreceptor tyrosine‐based inhibition motif (ITIM) was first identified in the
intracytoplasmic domain of FcγRIIB, ITIMs have been found in a large number of inhibitory …

The transplant of organs is one of the greatest therapeutic achievements of the twentieth
century. In organ transplantation, the adaptive immunity is considered the main response …

Natural killer (NK) cells recognize the absence of self MHC class I as a way to discriminate
normal cells from cells in distress. In humans, this" missing self" recognition is ensured by …

Conserved molecular patterns derived from pathogenic microorganisms prime antigen-
presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus …

NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in
natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in …

Inhibitory receptors that engage self-MHC class I molecules enable NK cells to detect
disease-associated loss of MHC class I on surrounding cells. Previous studies showed that …

Cytomegalovirus is the leading cause of congenital viral disease and the most important
opportunistic infection in immunocompromised patients,. We have used a mouse …

Human NK cells are characterized by the expression of surface receptors of the killer cell Ig-
like receptor (KIR) family, which are involved in the specific recognition of pathogenic target …

Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a
semiquantitative cell–cell adhesion assay as well as class I/peptide tetramers to provide a …

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to
proliferate. The rate-limiting step in this pathway is catalysed by carbamoyl phosphate …