The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

Heart development is exquisitely sensitive to the precise temporal regulation of thousands of
genes that govern developmental decisions during differentiation. However, we currently …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can
potentially be accomplished using the processes of dedifferentiation, transdifferentiation or …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical
for self-renewal maintenance. However, it remains unclear whether these networks …

Generation of induced pluripotent stem cells typically requires the ectopic expression of
transcription factors to reactivate the pluripotency network. However, it remains largely …

The reprogramming factors that induce pluripotency have been identified primarily from
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that …