Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …

Background There is increasing evidence linking alterations of the gut microbial composition
during early infancy to the development of atopic diseases and asthma. However, few …

Rationale: A link among sphingolipids, 17q21 genetic variants, and childhood asthma has
been suggested, but the underlying mechanisms and characteristics of such an asthma …

Asthma is a highly heterogeneous disease, but the pathogenesis of asthma is still unclear. It
is well known that the airway inflammatory immune response is the pathological basis of …

The increasing knowledge of the mechanisms involved in metabolism is shifting the
paradigms by which the pathophysiology of many pulmonary diseases is understood …

Asthma in children remains a significant public health challenge affecting 5–20% of children
in Europe and is associated with increased morbidity and societal healthcare costs. The …

Several metabolomics studies have identified altered metabolic pathways that are related to
asthma. However, an integrative analysis of the metabolic responses across blood and urine …

Wheezing is one of the characteristic symptoms of asthma, but all preschool children with
wheezing are not diagnosed with asthma. Preschool children are not cooperative enough to …

Asthma, allergic rhinitis, food allergy, and atopic dermatitis are common childhood diseases
with several different underlying mechanisms, ie, endotypes of disease. Metabolomics has …