The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …

ABSTRACT Introduction Intestinal permeation enhancers (PEs) are substances that
transiently alter the intestinal epithelial barrier to facilitate permeation of macromolecules …

Functional-related characteristics (FRCs) are properties of excipients that can potentially
influence one or more functions of that excipient in the final product. Knowledge of FRCs is …

The series of conferences of the Global Bioequivalence Harmonisation Initiative (GBHI) was
started in 2015 by the European Federation for Pharmaceutical Sciences (EUFEPS). All …

This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor
aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When …

Drug release performance of tablets is often highly dependent on disintegration, and water
ingress is typically the rate-limiting step of the disintegration process. Water ingress into …

Here, the formulation of a novel bilayer tablet comprising a vitamin B 6 rapid-release layer
and a melatonin sustained-release layer is described. The effects of viscosity and …

The simulation of antral conditions for estimating drug apparent equilibrium solubility after a
high-calorie, high-fat meal is challenging. In this study,(1) we measured the apparent …

Introduction Excipients are necessary to develop oral dosage forms of any Active
Pharmaceutical Ingredient (API). Traditionally, excipients have been considered inactive …