Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses

G Wang, C Haringa, W Tang… - Biotechnology and …, 2020 - Wiley Online Library
Metabolomics aims to address what and how regulatory mechanisms are coordinated to
achieve flux optimality, different metabolic objectives as well as appropriate adaptations to …

Harnessing microbial metabolomics for industrial applications

J Zhao, G Wang, J Chu, Y Zhuang - World Journal of Microbiology and …, 2020 - Springer
Metabolome defines a set of metabolites present in a biological sample, which provides an
immediate and dynamic recording of microbes in response to genetic and/or environmental …

Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of Streptomyces albidoflavus

Á Pérez-Valero, J Serna-Diestro… - International Journal of …, 2024 - mdpi.com
Flavonoids exhibit various bioactivities including anti-oxidant, anti-tumor, anti-inflammatory,
and anti-viral properties. Methylated flavonoids are particularly significant due to their …

Impact of Altered Trehalose Metabolism on Physiological Response of Penicillium chrysogenum Chemostat Cultures during Industrially Relevant Rapid Feast/Famine …

X Wang, J Zhao, J Xia, G Wang, J Chu, Y Zhuang - Processes, 2021 - mdpi.com
Due to insufficient mass transfer and mixing issues, cells in the industrial-scale bioreactor
are often forced to experience glucose feast/famine cycles, mostly resulting in reduced …

Towards closed carbon loop fermentations: Cofeeding of Yarrowia lipolytica with glucose and formic acid

WA van Winden, R Mans, S Breestraat… - Biotechnology and …, 2022 - Wiley Online Library
A novel fermentation process was developed in which renewable electricity is indirectly
used as an energy source in fermentation, synergistically decreasing both the consumption …

Changes in Oxygen Availability during Glucose-Limited Chemostat Cultivations of Penicillium chrysogenum Lead to Rapid Metabolite, Flux and Productivity …

Q Yang, W Lin, J Xu, N Guo, J Zhao, G Wang, Y Wang… - Metabolites, 2022 - mdpi.com
Bioreactor scale-up from the laboratory scale to the industrial scale has always been a
pivotal step in bioprocess development. However, the transition of a bioeconomy from …

Harnessing Dynamic Metabolomics for Bioprocess Prediction and Beyond

G Wang, C Haringa, J Chu, Y Zhuang… - Handbook of …, 2024 - taylorfrancis.com
As the youngest of the quartet of systems biology tools alongside genomics, transcriptomics,
and proteomics, metabolomics provides an immediate and dynamic recording of cells in …

An industrial perspective on metabolic responses of Penicillium chrysogenum to periodic dissolved oxygen feast‐famine cycles in a scale‐down system

X Wang, Q Yang, C Haringa, Z Wang, J Chu… - Biotechnology and … - Wiley Online Library
While traveling through different zones in large‐scale bioreactors, microbes are most likely
subjected to fluctuating dissolved oxygen (DO) conditions at the timescales of global …

Penicillium chrysogenum: Beyond the penicillin.

C Barreiro, SM Albillos… - Advances in Applied …, 2024 - europepmc.org
Almost one century after the Sir Alexander Fleming's fortuitous discovery of penicillin and the
identification of the fungal producer as Penicillium notatum, later Penicillium chrysogenum …

[PDF][PDF] Mitochondria i bilans energetyczny komórki w biotechnologii

SA Porębski - naukowcy.org.pl
WSTęP Mitochondria (z greckiego mitos–nić, chondros–ziarno) są kluczowymi dla
energetyki komórki organellami. Zostały one pierwszy raz zaobserwowane przez Köllikera w …