Clinical and Preclinical Methods of Heat-Stabilization of Human Vaccines
GL Williamson, EM Bachelder… - Molecular …, 2024 - ACS Publications
Vaccines have historically faced challenges regarding stability, especially in regions lacking
a robust cold chain infrastructure. This review delves into established and emergent …
a robust cold chain infrastructure. This review delves into established and emergent …
Zinc Carnosine Metal–Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability
Current seasonal influenza vaccines are limited in that they need to be reformulated every
year in order to account for the constant mutation of the virus. Hemagglutinin (HA) …
year in order to account for the constant mutation of the virus. Hemagglutinin (HA) …
Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine
The most common influenza vaccines are inactivated viruses produced in chicken eggs,
which is a time-consuming production method with variable efficacy due to mismatches of …
which is a time-consuming production method with variable efficacy due to mismatches of …
A bioactive sprite: Recent advances in the application of vinyl sulfones in drug design and organic synthesis
J Tong, J Shu, Y Wang, Y Qi, Y Wang - Life Sciences, 2024 - Elsevier
Vinyl sulfones, with their exceptional chemical properties, are known as the “chameleons” of
organic synthesis and are widely used in the preparation of various sulfur-containing …
organic synthesis and are widely used in the preparation of various sulfur-containing …
Cobra Hemagglutinin and cGAMP Loaded Ace‐Dex Microparticles Provide a Broadly Active and Shelf‐Stable Influenza Vaccine Platform
Current FDA‐approved influenza vaccines are limited by variable year to year efficacy, low
immunogenicity, and poor stability outside of cold‐chain storage. Polymeric microparticles …
immunogenicity, and poor stability outside of cold‐chain storage. Polymeric microparticles …
Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations
Influenza virus outbreaks are a major burden worldwide each year. Current vaccination
strategies are inadequate due to antigenic drift/shift of the virus and the elicitation of low …
strategies are inadequate due to antigenic drift/shift of the virus and the elicitation of low …
Polymeric cGAMP microparticles affect the immunogenicity of a broadly active influenza mRNA lipid nanoparticle vaccine
Influenza outbreaks are a major burden worldwide annually. While seasonal vaccines do
provide protection against infection, they are limited in that they need to be updated every …
provide protection against infection, they are limited in that they need to be updated every …
Enhancement of subunit vaccine delivery with zinc-carnosine coordination polymer through the addition of mannan
Vaccines represent a pivotal health advancement for preventing infection. However,
because carrier systems with repeated administration can invoke carrier-targeted immune …
because carrier systems with repeated administration can invoke carrier-targeted immune …
Recent Advances in Drug Delivery
AK Salem - The AAPS Journal, 2024 - Springer
In this special collection, a review on delivery strategies for RNA therapies is presented by
Dr. Oh. The review discusses different strategies employed in the design and development …
Dr. Oh. The review discusses different strategies employed in the design and development …
[HTML][HTML] Multi-COBRA hemagglutinin formulated with cGAMP microparticles elicit protective immune responses against influenza viruses
Influenza viruses cause a common respiratory disease known as influenza. In humans,
seasonal influenza viruses can lead to epidemics, with avian influenza viruses of particular …
seasonal influenza viruses can lead to epidemics, with avian influenza viruses of particular …