Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …

Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

Objectives: We performed a national cross-sectional survey to determine the epidemiologic
characteristics of patients with sepsis in ICU in China. Design: A cross-section survey study …

Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.
Objectives: To evaluate the association between antibiotic timing and mortality among …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Importance The Third International Consensus Definitions Task Force defined sepsis as “life-
threatening organ dysfunction due to a dysregulated host response to infection.” The …

Importance Septic shock currently refers to a state of acute circulatory failure associated with
infection. Emerging biological insights and reported variation in epidemiology challenge the …

Rationale: Reducing the global burden of sepsis, a recognized global health challenge,
requires comprehensive data on the incidence and mortality on a global scale. Objectives …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Severe sepsis is a leading cause of death in the United States and the most common cause
of death among critically ill patients in non-coronary intensive care units (ICU). Respiratory …