Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Simple Summary High-grade serous ovarian cancer (HGSOC) is the most prevalent type of
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …

Background Rheumatoid arthritis (RA) is an inflammatory debilitating disease that affects the
joints in the early and productive phases of an individual's life. Several cytokines have been …

The protein chaperone GRP78 is a master regulator of endoplasmic reticulum (ER) functions
and is frequently over-expressed at the surface of cancer cells where it contributes to chemo …

Ovarian cancer remains the most lethal gynecological malignancy. Ferroptosis, a
specialized form of iron-dependent, nonapoptotic cell death, plays a crucial role in various …

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated
intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic …

Lung cancer, primarily non-small-cell lung cancer (NSCLC), is a significant cause of cancer-
related mortality worldwide. Cisplatin-based chemotherapy is a standard treatment for …

The endoplasmic reticulum (ER), an organelle present in various eukaryotic cells, is
responsible for intracellular protein synthesis, post-translational modification, and folding …

Despite advances in cancer therapy, several persistent issues remain. These include cancer
recurrence, effective targeting of aggressive or therapy-resistant cancers, and selective …