Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Design of virus-based nanomaterials for medicine, biotechnology, and energy

AM Wen, NF Steinmetz - Chemical Society Reviews, 2016 - pubs.rsc.org
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …

DNA replicons for plant genome engineering

NJ Baltes, J Gil-Humanes, T Cermak, PA Atkins… - The Plant …, 2014 - academic.oup.com
Sequence-specific nucleases enable facile editing of higher eukaryotic genomic DNA;
however, targeted modification of plant genomes remains challenging due to ineffective …

Plant‐made vaccines for humans and animals

EP Rybicki - Plant biotechnology journal, 2010 - Wiley Online Library
The concept of using plants to produce high‐value pharmaceuticals such as vaccines is 20
years old this year and is only now on the brink of realisation as an established technology …

Advances in plant molecular farming

OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Putting the spotlight back on plant suspension cultures

RB Santos, R Abranches, R Fischer, M Sack… - Frontiers in plant …, 2016 - frontiersin.org
Plant cell suspension cultures have several advantages that make them suitable for the
production of recombinant proteins. They can be cultivated under aseptic conditions using …

Plant molecular farming of virus‐like nanoparticles as vaccines and reagents

EP Rybicki - Wiley Interdisciplinary Reviews: Nanomedicine …, 2020 - Wiley Online Library
The use of plants for the production of virus‐like nanoparticles (VNPs) dates back to
separating natural empty capsids of plant viruses from whole virions nearly 70 years ago …

The arms race between Magnaporthe oryzae and rice: Diversity and interaction of Avr and R genes

B Wang, DJ Ebbole, Z Wang - Journal of Integrative Agriculture, 2017 - Elsevier
Rice blast disease, caused by Magnaporthe oryzae, threatens global food security. The rice
blast pathosystem is a longstanding model system for understanding plant-microbe …

When plant virology met Agrobacterium: the rise of the deconstructed clones

H Peyret, GP Lomonossoff - Plant biotechnology journal, 2015 - Wiley Online Library
In the early days of molecular farming, Agrobacterium‐mediated stable genetic
transformation and the use of plant virus‐based vectors were considered separate and …

Plant Viral Vectors for Delivery by Agrobacterium

YY Gleba, D Tusé, A Giritch - Plant viral vectors, 2013 - Springer
Plant viral vectors delivered by Agrobacterium are the basis of several manufacturing
processes that are currently in use for producing a wide range of proteins for multiple …