Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …

Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …

The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur
in the organization, composition, and mechanical properties of the extracellular matrix …

The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …

Objective—Inflammatory activation of valve endothelium is an early phase of aortic valve
disease pathogenesis, but subsequent mechanisms are poorly understood. Adult valve …

Valvular inflammation triggered by hyperlipidemia has been considered as an important
initial process of aortic valve disease; however, cellular and molecular evidence remains …

Arterial endothelial cells maintain vascular homeostasis and vessel tone in part through the
secretion of nitric oxide (NO). In this study, we determined how aortic valve endothelial cells …

This review highlights aspects of calcific aortic valve disease that encompass the entire
range of aortic valve disease progression from initial cellular changes to aortic valve …

Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now
recognized to be an active pathobiological process, with chronic inflammation emerging as …

In calcific aortic valve disease, fibrotic and calcific lesions form focally in the fibrosa layer of
the valve leaflets. Layer-specific pathosusceptibility suggests that the fibrosa …