Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease

K Donald, BB Finlay - Nature Reviews Immunology, 2023 - nature.com
Prenatal and early postnatal life represent key periods of immune system development. In
addition to genetics and host biology, environment has a large and irreversible role in the …

Challenges in exploring and manipulating the human skin microbiome

M Boxberger, V Cenizo, N Cassir, B La Scola - Microbiome, 2021 - Springer
The skin is the exterior interface of the human body with the environment. Despite its harsh
physical landscape, the skin is colonized by diverse commensal microbes. In this review, we …

The role of lung and gut microbiota in the pathology of asthma

W Barcik, RCT Boutin, M Sokolowska, BB Finlay - Immunity, 2020 - cell.com
Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

Enabling sustainable agriculture through understanding and enhancement of microbiomes

P Trivedi, C Mattupalli, K Eversole, JE Leach - New Phytologist, 2021 - Wiley Online Library
Harnessing plant‐associated microbiomes offers an invaluable strategy to help agricultural
production become more sustainable while also meeting growing demands for food, feed …

Dysbiosis of the gut and lung microbiome has a role in asthma

K Hufnagl, I Pali-Schöll, F Roth-Walter… - Seminars in …, 2020 - Springer
Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

E von Mutius, HH Smits - The Lancet, 2020 - thelancet.com
Asthma is a complex disease that often starts in childhood. Genomic and environmental
factors as well as aberrant immune maturation early in life can contribute to the onset of …

[HTML][HTML] S3 guideline allergy prevention

MV Kopp, C Muche-Borowski, M Abou-Dakn… - Allergologie …, 2022 - ncbi.nlm.nih.gov
Background: The persistently high prevalence of allergic diseases in Western industrial
nations and the limited possibilities of causal therapy make evidence-based …

[HTML][HTML] A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in …

MI Roslund, A Parajuli, N Hui, R Puhakka… - Ecotoxicology and …, 2022 - Elsevier
Background According to the biodiversity hypothesis of immune-mediated diseases, lack of
microbiological diversity in the everyday living environment is a core reason for …

[HTML][HTML] Indoor microbiome, air pollutants and asthma, rhinitis and eczema in preschool children–a repeated cross-sectional study

Y Sun, Y Meng, Z Ou, Y Li, M Zhang, Y Chen… - Environment …, 2022 - Elsevier
Background Indoor microbiome exposure is associated with asthma, rhinitis and eczema.
However, no studies report the interactions between environmental characteristics, indoor …