Mammalian skeletal muscle shows an enormous variability in its functional features such as
rate of force production, resistance to fatigue, and energy metabolism, with a wide spectrum …

Calcium (Ca2+) plays a pivotal role in almost all cellular processes and ensures the
functionality of an organism. In skeletal muscle fibers, Ca2+ is critically involved in the …

Release of Ca2+ ions from intracellular stores can occur via two classes of Ca2+-release
channel (CRC) protein, the inositol 1, 4, 5-trisphosphate receptors (Ins P 3Rs) and the …

Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has
been considered simply a passive Ca2+-buffering protein in the sarcoplasmic reticulum (SR) …

Introduction Skeletal muscles contain large numbers of high-molecular-mass protein
complexes in elaborate membrane systems. Integral membrane proteins are involved in …

Glycolysis represents one of the best-understood and most ancient metabolic pathways. In
skeletal muscle fibres, energy for contraction is supplied by adenosine triphosphate via …

Tubular aggregates are observed in various muscle disorders and appear as densely
packed tubules believed to arise from sarcoplasmic reticulum of striated muscle. They are …

Although calsequestrin (CASQ), a major sarcoplasmic reticulum (SR) Ca2+ binding protein,
was discovered more than 30 years ago, its precise roles and modes of operation in both …

Introduction The endoplasmic reticulum (ER) stress-response, evoked in mice by the
overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed …

Although all muscle cells generate contractile forces by means of organized filament
systems, isoform expression patterns of contractile and regulatory proteins in heart are not …