Background H syndrome is an autosomal recessive genodermatosis with multisystem
involvement caused by mutations in SLC29A3. Objective We sought to investigate the …

Abstract Tocilizumab, an anti-interleukin-6 (IL-6) agent, is indicated as a treatment for
several autoimmune or inflammatory diseases, including rheumatoid arthritis and juvenile …

During the past 15 years, a growing number of monogenic inflammatory diseases have
been described and their respective responsible genes identified. The proteins encoded by …

Background H Syndrome is an autosomal recessive disorder characterized by cutaneous
hyperpigmentation, hypertrichosis, and induration with numerous systemic manifestations …

Objectives Monogenic autoinflammatory disorders (AID) and primary immunodeficiencies
can present early in life with features that may be mistaken for Behçet's disease (BD). We …

Dorfman disease, and histiocytosis-lymphadenopathy-plus syndrome. Autoinflammation is
increasingly recognized in these syndromes. We previously reported a 16-year-old girl with …

The objective of this study was to determine how prenatal and postnatal dietary omega‐3
fatty acids alter white blood cell (leukocyte) DNA methylation of offspring. Fifteen gilts (n= 5 …

Simple Summary Anticancer nucleoside analogs are promising treatments that often result
in damaging toxicities and therefore ineffective treatment. Mechanisms of this are not well …

Although a majority of children and adults with diabetes mellitus (DM) are diagnosed with
type 1 diabetes mellitus (T1D) or type 2 diabetes mellitus (T2D), a significant number of …

The innate immune system is involved in the pathophysiology of systemic autoinflammatory
diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of …