Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Among age-related diseases, cardiovascular and cerebrovascular diseases are major
causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age …

The endothelium, by area alone, is one of the largest organs in the body comprised of up to
trillion cells, weighing over 1 kg, and covering nearly 3 m2 in a 70 kg male. 1, 2 Moreover, it …

Oral appliances (OA) have emerged as an alternative to continuous positive airway pressure
(CPAP) for obstructive sleep apnea (OSA) treatment. The most commonly used OA reduces …

The development of novel, non-invasive techniques and standardization of protocols to
assess microvascular dysfunction have elucidated the key role of microvascular changes in …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular
health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this …