Over the past 300 years, the migraine field has been dominated by two main theories—the
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …

An expansion of Simons’ integrated hypothesis of trigger point formation Page 1 An
Expansion of Simons’ Integrated Hypothesis of Trigger Point Formation Robert D. Gerwin …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Migraine is a highly prevalent neurovascular disorder that can be provoked by infusion of
calcitonin gene-related peptide (CGRP). CGRP, a neuropeptide released from activated …

Migraine is a common neurological disorder that is associated with an increase in plasma
calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from …

Termination of synaptic transmission by neurotransmitter hydrolysis is a substantial
characteristic of cholinergic synapses. This unique termination mechanism makes …

Migraine is a highly prevalent headache disease that typically affects patients during their
most productive years. Despite significant progress in understanding the underlying …

We have examined the progression of vascular and neural deficits in Zucker rats, Zucker
diabetic fatty (ZDF) diabetic rats, and age-matched lean ZDF rats from 8 to 40 wk of age …

Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral
nervous systems, consistent with control of vasodilatation, nociception, motor function …

Molecular mechanisms that are associated with age-related denervation and loss of skeletal
muscle mass and function (sarcopenia) are described for female C57Bl/6J mice aged 3, 15 …