Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer
A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
5-Oxo-hexahydroquinoline: An attractive scaffold with diverse biological activities
Oxo-hexahydroquinoline (5-oxo-HHQ) represents a biologically attractive fused heterocyclic
core. Various synthetic analogs of 5-oxo-HHQ have been synthesized and assessed for …
core. Various synthetic analogs of 5-oxo-HHQ have been synthesized and assessed for …
Design, synthesis, molecular modeling and anti-HIV assay of novel quinazolinone incorporated coumarin derivatives
M Safakish, Z Hajimahdi, MR Aghasadeghi… - Current HIV …, 2020 - ingentaconnect.com
Background: The emergence of drug-resistant viral strains has created the need for the
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …
[HTML][HTML] Design, synthesis and biological evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-quinoline derivatives as selective COX-2 inhibitors and in-vitro …
Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl
phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer …
phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer …
[HTML][HTML] Design, synthesis and biological evaluation of new 1, 4-dihydropyridine (DHP) derivatives as selective cyclooxygenase-2 inhibitors
I Sabakhi, V Topuzyan, Z Hajimahdi… - Iranian Journal of …, 2015 - ncbi.nlm.nih.gov
Design, Synthesis and Biological Evaluation of New 1, 4-Dihydropyridine (DHP) Derivatives
as Selective Cyclooxygenase-2 Inhibitors - PMC Back to Top Skip to main content NIH NLM …
as Selective Cyclooxygenase-2 Inhibitors - PMC Back to Top Skip to main content NIH NLM …
Docking-based 3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) study on hydroquinoline and thiazinan-4-one derivatives as selective COX-2 inhibitors
A Dowlati Beirami, Z Hajimahdi… - Journal of Biomolecular …, 2019 - Taylor & Francis
A series of 26 selective COX-2 inhibitors which reported previously by our laboratory was
selected to generate three-dimensional quantitative structure activity relationship (3D …
selected to generate three-dimensional quantitative structure activity relationship (3D …
Design, synthesis, and biological evaluation of new 1, 4‐diarylazetidin‐2‐one derivatives (β‐lactams) as selective cyclooxygenase‐2 inhibitors
H Arefi, N Naderi, ABI Shemirani… - Archiv Der …, 2020 - Wiley Online Library
Abstract A new series of 1, 4‐diarylazetidin‐2‐one derivatives (β‐lactams) were designed
and synthesized to evaluate their biological activities as selective cyclooxygenase‐2 (COX …
and synthesized to evaluate their biological activities as selective cyclooxygenase‐2 (COX …
[HTML][HTML] Evaluation of cytotoxicity effects of chalcone epoxide analogues as a selective COX-II inhibitor in the human liver carcinoma cell line
Objectives Study of the mechanisms involved in cancer progression suggests that
cyclooxygenase enzymes play an important role in the induction of inflammation, tumor …
cyclooxygenase enzymes play an important role in the induction of inflammation, tumor …
[HTML][HTML] QSAR modeling of COX-2 inhibitory activity of some dihydropyridine and hydroquinoline derivatives using multiple linear regression (MLR) method
COX-2 inhibitory activities of some 1, 4-dihydropyridine and 5-oxo-1, 4, 5, 6, 7, 8-
hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship …
hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship …
Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity
BB Chaudhari, A Bali, A Balaini - Medicinal Chemistry, 2021 - ingentaconnect.com
Background: NSAIDs are the most widely prescribed medications worldwide for their anti-
inflammatory, antipyretic, and analgesic effects. However, their chronic use can lead to …
inflammatory, antipyretic, and analgesic effects. However, their chronic use can lead to …