To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Many eukaryotic protein-coding genes are able to generate exonic circular RNAs. Most of
these covalently linked transcripts are expressed at low levels, but some accumulate to …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively
abundant have only recently begun to be explored. There are many thousands of genes that …

Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

Age-related hearing loss (ARHL) negatively impacts quality of life in the elderly population.
The prevalent cause of ARHL is loss of mechanosensitive cochlear hair cells (HCs). The …

Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse
species. However, only few circRNAs have been functionally characterized, and their role …

Circular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting
as a special covalent loop without a 5′ cap or 3′ tail. Multiple biological properties of …

Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes.
Recent studies indicate that the levels of circRNAs change with age in various tissues in …

Circular RNAs (circRNAs) are highly expressed in the brain and their expression increases
during neuronal differentiation. The factors regulating circRNAs in the developing mouse …