Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …

Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

It is well established that tumor-associated macrophages (TAM) found in most advanced
tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating …

Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible lung disease, and
developing an effective treatment remains a challenge. The limited therapeutic options are …

Numerous clinical and research investigations conducted during the last two decades have
implicated excessive oxidative stress caused by high levels of reactive oxygen species …

Abstract Fine particulate matter (PM2. 5) is an important component of air pollution and can
induce lung inflammation and oxidative stress. We hypothesized that PM2. 5 could play a …

Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative lung disease, and fibroblast-
myofibroblast differentiation (FMD) is thought to be a key event in the pathogenesis of IPF …

Background Pulmonary fibrosis is a major category of end-stage changes in lung diseases,
characterized by lung epithelial cell damage, proliferation of fibroblasts, and accumulation of …