Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and
immunotherapeutic targets. However, a greater understanding of their biology is necessary …

Chimeric antigen receptor (CAR) T cell is a T lymphocyte-based immunotherapy, which
achieves great successes in treating blood malignancies and provides new hope to cue …

Allogeneic cell therapies, defined by genetically mismatched transplantation, have the
potential to become a cost-effective solution for cell-based cancer immunotherapy. However …

Purpose: The development of allogeneic chimeric antigen receptor (CAR) T-cell therapies
for off-the-shelf use is a major goal that faces two main immunologic challenges, namely the …

Invariant natural killer T (iNKT) cells are immune cells that harness properties of both the
innate and adaptive immune system and exert multiple functions critical for the control of …

Invariant natural killer T (i NKT) cells are thymus-generated innate-like αβ T cells that
undergo terminal differentiation in the thymus. Such a developmental pathway differs from …

The" innate-like" T cell compartment, known as T inn, represents a diverse group of T cells
that straddle the boundary between innate and adaptive immunity. We explore the …

Cellular therapy with regulatory T cells (Tregs) has shown promising results for suppressing
graft-versus-host disease (GVHD) while preserving graft vs tumor effects in animal models …

Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine
remains a major problem in infection prevention. The lack of small animal models and …

Background: Immunological imbalances characteristic of endometriosis may develop as
early as the primary manifestations of the disease in adolescence. Objective: To evaluate …