Background Recently, numerous studies have reported the interaction between senescence
and oxidative stress in cancer. However, there is a lack of a comprehensive understanding …

Simple Summary Oral health is increasingly recognized as an important part of overall
health. Tooth loss is a contributor to overall musculoskeletal frailty and is closely associated …

Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly
challenge health conditions due to their detrimental effects on patient's digestive functions …

The global aging population has led to a rise in age-related health issues, such as
malnutrition, metabolic disorders, and even immune decline. Among these concerns …

Periodontitis is a prevalent disease and one of the leading causes of tooth loss. Biofilms are
initiating factor of periodontitis, which can destroy periodontal tissue by producing virulence …

Background Prolyl 4-hydroxylase subunit beta (P4HB) has been reported as a suppressor in
ferroptosis. However, no known empirical research has focused on exploring relationships …

Exosomes (exos) contain molecular cargo of therapeutic and diagnostic value for cancers
and other inflammatory diseases, but their therapeutic potential for periodontitis (PD) …

Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …

Background Cellular senescence is growing in popularity in cancer. A dual function is
played by the senescence-associated secretory phenotype (SASP) that senescent cells …

Periodontitis is a chronic inflammatory disease caused by dysbiotic biofilms and destructive
host immune responses. Extracellular vesicles (EVs) are circulating nanoparticles released …