Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …

BACKGROUND: Here, we assessed the role of cellular senescence and the senescence
associated secretory phenotype (SASP) in age-related aortic stiffening and endothelial …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Cellular senescence and the senescence‐associated secretory phenotype (SASP)
contribute to age‐related arterial dysfunction, in part, by promoting oxidative stress and …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …

Recent strides in anti-cancer therapeutics have improved longevity and led to a growing
population of cancer survivors, who are increasingly likely to die of other causes. Treatment …

We assessed the efficacy of oral supplementation with the flavanoid apigenin on arterial
function during aging and identified critical mechanisms of action. Young (6 mo) and old (27 …

Cardiovascular disease is the major cause of morbidity and mortality in breast cancer
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …