The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α
converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface …

We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell
(CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate
in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) …

Axon-derived molecules are temporally and spatially required as positive or negative
signals to coordinate oligodendrocyte differentiation. Increasing evidence suggests that, in …