Human Cytomegalovirus (HCMV) is an immensely pervasive herpesvirus, persistently
infecting high percentages of the world population. Despite the apparent robust host …

Herpesviruses are DNA viruses and the cause of diseases ranging from mild skin conditions
to severe brain diseases. Mammalian antiviral host defense comprises an array of …

Communication between infected cells and cells in the surrounding tissue is a determinant
of viral spread. However, it remains unclear how cells in close or distant proximity to an …

Malaria has had a major effect on the human genome, with many protective polymorphisms—
such as the sickle-cell trait—having been selected to high frequencies in malaria-endemic …

As the COVID-19 pandemic continues to spread, thousands of scientists around the globe
have changed research direction to understand better how the virus works and to find out …

Quantitative proteomics employing isobaric reagents has been established as a powerful
tool for biological discovery. Current workflows often utilize a dedicated quantitative …

Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine
deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic …

Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating> 900
human proteins during viral replication and degrading≥ 133 proteins shortly after infection …

Viruses are one of the major causes of acute and chronic infectious diseases and thus a
major contributor to the global burden of disease. Several studies have shown how viruses …

Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple
mechanisms of inhibition of interferon regulatory factor 3 (IRF-3), nuclear factor κB (NF-κB) …