Role of thymic stromal lymphopoietin in allergy and beyond

R Ebina-Shibuya, WJ Leonard - Nature Reviews Immunology, 2023 - nature.com
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Epithelial cell–derived cytokines: more than just signaling the alarm

F Roan, K Obata-Ninomiya… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma

GM Gauvreau, R Sehmi, CS Ambrose… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …

Thymic stromal lymphopoietin isoforms, inflammatory disorders, and cancer

G Varricchi, A Pecoraro, G Marone… - Frontiers in …, 2018 - frontiersin.org
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Sounding the alarmins—the role of alarmin cytokines in asthma

GM Gauvreau, C Bergeron, LP Boulet, DW Cockcroft… - Allergy, 2023 - Wiley Online Library
The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

MAM Willart, K Deswarte, P Pouliot, H Braun… - Journal of Experimental …, 2012 - rupress.org
House dust mite (HDM) is one of the most common allergens worldwide. In this study, we
have addressed the involvement of IL-1 in the interaction between HDM and the innate …

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

R Choa, J Tohyama, S Wada, H Meng, J Hu… - Science, 2021 - science.org
INTRODUCTION Obesity and its associated complications are serious global concerns.
Despite growing public health initiatives, obesity rates continue to rise. Thus, there is a …

Living and dying for inflammation: neutrophils, eosinophils, basophils

B Geering, C Stoeckle, S Conus, HU Simon - Trends in immunology, 2013 - cell.com
Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and
sterile inflammation. The severity of such inflammatory processes is controlled, at least in …

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization

DK Chu, A Llop-Guevara, TD Walker, K Flader… - Journal of Allergy and …, 2013 - Elsevier
BACKGROUND: Allergen exposure at lung and gut mucosae can lead to aberrant TH2
immunity and allergic disease. The epithelium-associated cytokines thymic stromal …