Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials

L Huang, K Trieu, S Yoshimura, B Neal, M Woodward… - bmj, 2020 - bmj.com
Objective To examine the dose-response relation between reduction in dietary sodium and
blood pressure change and to explore the impact of intervention duration. Design …

The future of thiazolidinedione therapy in the management of type 2 diabetes mellitus

H Yau, K Rivera, R Lomonaco, K Cusi - Current diabetes reports, 2013 - Springer
Since their approval, thiazolidinediones (TZDs) have been used extensively as insulin-
sensitizers for the management of type 2 diabetes mellitus (T2DM). Activation of peroxisomal …

Salt-sensitivity of blood pressure and insulin resistance

LA Ertuglu, F Elijovich, CL Laffer, A Kirabo - Frontiers in Physiology, 2021 - frontiersin.org
Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular
morbidity and mortality that is seen in both hypertensive and normotensive populations …

Do most patients with obesity or type 2 diabetes, and atrial fibrillation, also have undiagnosed heart failure? A critical conceptual framework for understanding …

M Packer - European journal of heart failure, 2020 - Wiley Online Library
Obesity and diabetes can lead to heart failure with preserved ejection fraction (HFpEF),
potentially because they both cause expansion and inflammation of epicardial adipose …

Redox homeostasis and epigenetics in non-alcoholic fatty liver disease (NAFLD)

C Podrini, M Borghesan, A Greco… - Current …, 2013 - ingentaconnect.com
Non-alcoholic fatty liver disease (NAFLD), an accumulation of intra-hepatic triglycerides that
is often considered the hepatic manifestation of insulin resistance, is the most common …

Comprehensive review of cardiovascular disease risk in nonalcoholic fatty liver disease

K Josloff, J Beiriger, A Khan, RJ Gawel… - Journal of …, 2022 - mdpi.com
Nonalcoholic Fatty Liver Disease (NAFLD) is a growing global phenomenon, and its
damaging effects in terms of cardiovascular disease (CVD) risk are becoming more …

Atrial fibrillation and heart failure with preserved ejection fraction in patients with nonalcoholic fatty liver disease

M Packer - The American Journal of Medicine, 2020 - Elsevier
The most common causes of chronic liver disease in the developed world—nonalcoholic
fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)—are the hepatic …

Efficacy and safety of sitagliptin for the treatment of new‐onset diabetes after renal transplantation

BP Boerner, CD Miles… - International Journal of …, 2014 - Wiley Online Library
New‐onset diabetes after transplantation (NODAT) is a common comorbidity after renal
transplantation. Though metformin is the first‐line agent for the treatment of type 2 diabetes …

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans

MH Gangadhariah, BW Dieckmann, L Lantier, L Kang… - Diabetologia, 2017 - Springer
Aims/hypothesis Insulin resistance is frequently associated with hypertension and type 2
diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) …

Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension

J Wu, LN Agbor, S Fang, M Mukohda… - Cardiovascular …, 2021 - academic.oup.com
Aims Salt-sensitive (SS) hypertension is accompanied by impaired vasodilation in the
systemic and renal circulation. However, the causal relationship between vascular …