The in vitro panel of technologies to address biomolecular interactions are in play, however
microscale thermophoresis is continuously increasing in use to represent a key player in this …

Pyrazinamide (PZA) has remained a keystone of tuberculosis (TB) therapy, and it possesses
high imperative sterilizing action that can facilitate reduction in the present chemotherapy …

Pyrazinamide (PZA) is considered to be a pivotal drug to shorten the treatment of both drug-
susceptible and drug-resistant tuberculosis, but its use is challenged by the reliability of drug …

Pyrazinamide (PZA) is one of the first-line agents used for the treatment of tuberculosis.
However, current phenotypic PZA susceptibility testing in the Bactec MGIT 960 system is …

Background Fatty acid metabolism greatly promotes the virulence and pathogenicity of
Mycobacterium tuberculosis (M. tb). However, the regulatory mechanism of fatty acid …

Because of the ever-increasing multidrug resistance in microorganisms, it is crucial that we
find and develop new antibiotics, especially molecules with different targets and …

This study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in
Southern China over 11 years (2012–2022) and evaluates the mutation characteristics of …

Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and
morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen …

In the present study, a new series of diazenyl azo-phenol derivatives (TC-1 to TC-8) have
been synthesized via diazo-coupling approach between substituted aromatic amines and …

Targeting translation factor proteins holds promise for developing innovative anti-
tuberculosis drugs. During protein translation, many factors cause ribosomes to stall at …