EBV-associated diseases: Current therapeutics and emerging technologies
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …
Spectrum of Epstein-Barr virus–associated diseases
JL Kutok, F Wang - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
The association between Epstein-Barr virus (EBV) and a large number of benign and
malignant diseases is unique among DNA viruses. Within infected tissues, proteins that are …
malignant diseases is unique among DNA viruses. Within infected tissues, proteins that are …
Viral latency and its regulation: lessons from the γ-herpesviruses
SH Speck, D Ganem - Cell host & microbe, 2010 - cell.com
Latency is a state of cryptic viral infection associated with genomic persistence and highly
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …
Notch signaling in cancer
EJ Allenspach, I Maillard, JC Aster… - Cancer biology & …, 2002 - Taylor & Francis
Notch signaling plays a key role in the normal development of many tissues and cell types,
through diverse effects on differentiation, survival, and/or proliferation that are highly …
through diverse effects on differentiation, survival, and/or proliferation that are highly …
Pathogenesis and host control of gammaherpesviruses: lessons from the mouse
E Barton, P Mandal, SH Speck - Annual review of immunology, 2011 - annualreviews.org
Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …
The role of gammaherpesviruses in cancer pathogenesis
Worldwide, one fifth of cancers in the population are associated with viral infections. Among
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
Cancers associated with human gammaherpesviruses
KW Wen, L Wang, JR Menke, B Damania - The FEBS journal, 2022 - Wiley Online Library
Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
JJD Hsieh, S Zhou, L Chen… - Proceedings of the …, 1999 - National Acad Sciences
CBF1 is a member of the CSL family of DNA binding factors, which mediate either
transcriptional repression or transcriptional activation. CSL proteins play a central role in …
transcriptional repression or transcriptional activation. CSL proteins play a central role in …
Role of NF-κB in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells
ED Cahir-McFarland, K Carter, A Rosenwald… - Journal of …, 2004 - Am Soc Microbiol
Epstein-Barr virus (EBV) latency III infection converts B lymphocytes into lymphoblastoid cell
lines (LCLs) by expressing EBV nuclear and membrane proteins, EBNAs, and latent …
lines (LCLs) by expressing EBV nuclear and membrane proteins, EBNAs, and latent …
NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells
ED Cahir-McFarland, DM Davidson… - Proceedings of the …, 2000 - National Acad Sciences
Epstein–Barr virus (EBV) transforms B lymphocytes into lymphoblastoid cell lines usurping
the Notch and tumor necrosis factor receptor pathways to effect transcription including NF-κB …
the Notch and tumor necrosis factor receptor pathways to effect transcription including NF-κB …