Autophagy and cancer drug resistance in dialogue: pre-clinical and clinical evidence
Y Qin, M Ashrafizadeh, V Mongiardini, B Grimaldi… - Cancer letters, 2023 - Elsevier
The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …
categorized as acquired or intrinsic; the alteration of several biological mechanisms …
[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
[HTML][HTML] Protein degradation: expanding the toolbox to restrain cancer drug resistance
Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …
obstacle. Recent research based on protein degradation to restrain drug resistance has …
[HTML][HTML] Modulation of redox homeostasis: A strategy to overcome cancer drug resistance
Cancer treatment is hampered by resistance to conventional therapeutic strategies,
including chemotherapy, immunotherapy, and targeted therapy. Redox homeostasis …
including chemotherapy, immunotherapy, and targeted therapy. Redox homeostasis …
[HTML][HTML] Recent advances in cellular signaling interplay between redox metabolism and autophagy modulation in cancer: an overview of molecular mechanisms and …
Autophagy is a fundamental homeostatic process in which certain cellular components are
ingested by double-membrane autophagosomes and then degraded to create energy or to …
ingested by double-membrane autophagosomes and then degraded to create energy or to …
HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation
Abstract BRAF V600E attracts wide attention in the treatment of colorectal cancer (CRC) as
stratifying and predicting a refractory classification of CRC. Recent evidence indicates that …
stratifying and predicting a refractory classification of CRC. Recent evidence indicates that …
Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy
Emerging evidence indicates that cancer cells can mimic characteristics of embryonic
development, promoting their development and progression. Cancer cells share features …
development, promoting their development and progression. Cancer cells share features …
Redox signaling-mediated tumor extracellular matrix remodeling: pleiotropic regulatory mechanisms
Background The extracellular matrix (ECM), a fundamental constituent of all tissues and
organs, is crucial for shaping the tumor microenvironment. Dysregulation of ECM …
organs, is crucial for shaping the tumor microenvironment. Dysregulation of ECM …
[HTML][HTML] Awakening of Dormant Breast Cancer Cells in the Bone Marrow
R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer cells travel via the bloodstream to the bone before the
cancer is detectable in the breast. These disseminated cells are resistant to adjuvant …
cancer is detectable in the breast. These disseminated cells are resistant to adjuvant …
[HTML][HTML] Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer
K Ding, H Tian, L Li, Z Wang, S Liu, N Ding… - Journal of …, 2024 - Springer
Multi-modal combination therapy is regarded as a promising approach to cancer treatment.
Combining chemotherapy and phototherapy is an essential multi-modal combination …
Combining chemotherapy and phototherapy is an essential multi-modal combination …