Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Individuals with Down syndrome (DS) commonly possess unique neurocognitive and
neurobehavioral profiles that emerge within specific developmental periods. These profiles …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …

Synaptic failure is an immediate cause of cognitive decline and memory dysfunction in
Alzheimer's disease. Dendritic spines are specialized structures on neuronal processes, on …

Environmental enrichment (EE) is known to profoundly affect the central nervous system
(CNS) at the functional, anatomical and molecular level, both during the critical period and …

Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive
dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and …

Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a
condition that could compromise synaptic plasticity and mnemonic processing. We show that …

Substantial progress has been made toward understanding the neuropathology, genetic
origins, and epidemiology of neurodegenerative diseases, including Alzheimer's disease; …