Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Ras mutations (eg, occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and
promising drug targets in chemotherapy treatments for cancer. However, there are still no …

Antimicrobial peptides (AMPs) have been described as one of the most promising
compounds able to address one of the main health threats of the twenty-first century that is …

The use of biologics (peptide and protein based drugs) has increased significantly over the
past few decades. However, their development has been limited by their short half-life …

The Wnt signaling pathway plays a critical role in cell proliferation and differentiation, thus it
is often associated with diseases such as cancers. Unfortunately, although attractive …

Cell‐penetrating peptides (CPPs) can transport various cargoes through membranes of live
cells. Since the first generations of CPPs suffered from insufficient cell and tissue selectivity …

Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

Nullomers are the shortest strings of absent amino acid (aa) sequences in a species or
group of species. Primes are those nullomers that have not been detected in the genome of …

Cell penetrating peptides (CPPs) play a crucial role in the transportation of bioactive
molecules. Although CPPs have been used widely in various delivery systems, further …