Sex neurosteroids: Hormones made by the brain for the brain
L Fester, GM Rune - Neuroscience Letters, 2021 - Elsevier
In general, hippocampal neurons are capable of synthesizing sex steroids de novo from
cholesterol, since the brain is equipped with all the enzymes required for the synthesis of …
cholesterol, since the brain is equipped with all the enzymes required for the synthesis of …
Impacts of sleep loss versus waking experience on brain plasticity: parallel or orthogonal?
Recent studies on the effects of sleep deprivation on synaptic plasticity have yielded
discrepant results. Sleep deprivation studies using novelty exposure as a means to keep …
discrepant results. Sleep deprivation studies using novelty exposure as a means to keep …
Estrogen receptor profiles across tissues from male and female Rattus norvegicus
DD Hutson, R Gurrala, BO Ogola… - Biology of sex …, 2019 - Springer
Background Estrogen is formed by the enzyme aromatase (CYP19A1) and signals via three
identified receptors ERα (ESR1), ERß (ESR2), and the G protein-coupled estrogen receptor …
identified receptors ERα (ESR1), ERß (ESR2), and the G protein-coupled estrogen receptor …
Current best practices for analysis of dendritic spine morphology and number in neurodevelopmental disorder research
Quantitative methods for assessing neural anatomy have rapidly evolved in neuroscience
and provide important insights into brain health and function. However, as new techniques …
and provide important insights into brain health and function. However, as new techniques …
Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging
Research in preclinical models indicates that estrogens are neuroprotective and positively
impact cognitive aging. However, clinical data are equivocal as to the benefits of …
impact cognitive aging. However, clinical data are equivocal as to the benefits of …
Functional connectome dynamics after mild traumatic brain injury according to age and sex
Neural and cognitive deficits after mild traumatic brain injury (mTBI) are paralleled by
changes in resting state functional correlation (FC) networks that mirror post-traumatic …
changes in resting state functional correlation (FC) networks that mirror post-traumatic …
Estrogen-dependent hippocampal wiring as a risk factor for age-related dementia in women
Women are more prone than men to develop age-related dementia, such as Alzheimer's
disease (AD). This has been linked to the marked decrease in circulating estrogens during …
disease (AD). This has been linked to the marked decrease in circulating estrogens during …
Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43A315T Mouse Model of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex
function affected early in disease. Younger females have a lower relative risk of succumbing …
function affected early in disease. Younger females have a lower relative risk of succumbing …
Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
impaired social interactions, communication deficits and repetitive behaviors. A study of …
impaired social interactions, communication deficits and repetitive behaviors. A study of …
Sex‐dependency of oestrogen‐induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents
N Brandt, GM Rune - European Journal of Neuroscience, 2020 - Wiley Online Library
Sex‐dependent differences in learning and memory formation in humans have been
frequently shown. The mechanisms underlying the formation and retention of memories are …
frequently shown. The mechanisms underlying the formation and retention of memories are …