In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …

Increases in the incidence and mortality due to the major invasive fungal infections such as
aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida …

As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of
the innate immune response, and yet the commensal fungus Candida albicans is able to …

Fungi are surrounded by a rigid structure, the fungal cell wall. Its plasticity and composition
depend on active regulation of the underlying biosynthesis and restructuring processes. This …

Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …

Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

ABSTRACT Calcium (Ca2+) is a universal signalling molecule of life. The Ca2+ signalling is
an evolutionarily conserved process from prokaryotes to eukaryotes. Ca2+ at high …

Calcineurin signaling plays diverse roles in fungi in regulating stress responses,
morphogenesis and pathogenesis. Although calcineurin signaling is conserved among …

Ca2+, as a second messenger in cells, enables organisms to adapt to different
environmental stresses by rapidly sensing and responding to external stimuli. In recent …