T-type calcium channels are critically important for regulating neuronal excitability, both in
the central and peripheral nervous system, and are essential mediators of hormone …

Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …

L-type Ca2+ channels are broadly expressed in arterial smooth muscle cells, and their
voltage-dependent properties are important in tone development. Recent studies have …

This review summarizes recent advances in our understanding of neuronal T–type calcium
channel regulation as well as their physiological and pathophysiological roles. Through their …

Besides controlling a wide variety of cell functions, T-type channels have been shown to
regulate neurotransmitter release in peripheral and central synapses and neuroendocrine …

Adrenal medullary chromaffin cells are a major peripheral output of the sympathetic nervous
system. Catecholamine release from these cells is driven by synaptic excitation from the …

Voltage gated Ca2+ channels are effective voltage sensors of plasma membrane which
convert cell depolarizations into Ca2+ signaling. The chromaffin cells of the adrenal medulla …

Key points Mouse chromaffin cells (MCCs) of the adrenal medulla possess fast‐inactivating
Nav channels whose availability alters spontaneous action potential firing patterns and the …

Key points Tymothy syndrome (TS) is a multisystem disorder featuring cardiac arrhythmias,
autism and adrenal gland dysfunction that originates from a de novo point mutation in the …

Adrenal chromaffin cells (CCs) are the main source of circulating catecholamines (CAs) that
regulate the body response to stress. Release of CAs is controlled neurogenically by the …