Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Krüppel-like factors in cancer

MP Tetreault, Y Yang, JP Katz - Nature Reviews Cancer, 2013 - nature.com
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation …

The FUS/circEZH2/KLF5/feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

P Liu, Z Wang, X Ou, P Wu, Y Zhang, S Wu, X Xiao… - Molecular cancer, 2022 - Springer
Background Metastasis of breast cancer have caused the majority of cancer-related death
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …

The roles and regulation of the KLF5 transcription factor in cancers

Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

J Qin, Z Zhou, W Chen, C Wang, H Zhang, G Ge… - Nature …, 2015 - nature.com
The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes
breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in …

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

JT Dong, C Chen - Cellular and molecular life sciences, 2009 - Springer
Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …

The diverse functions of Krüppel‐like factors 4 and 5 in epithelial biology and pathobiology

BB McConnell, AM Ghaleb, MO Nandan, VW Yang - Bioessays, 2007 - Wiley Online Library
The Krüppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger
transcription factors that regulate numerous biological processes including proliferation …

KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2

L Jia, Z Zhou, H Liang, J Wu, P Shi, F Li, Z Wang… - Oncogene, 2016 - nature.com
The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and
basal-like breast cancers. However, the mechanism by which KLF5 promotes cell migration …

[HTML][HTML] Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

ARMR Amin, PA Karpowicz, TE Carey, J Arbiser… - Seminars in cancer …, 2015 - Elsevier
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …

Somatic superenhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor

X Zhang, PS Choi, JM Francis, GF Gao, JD Campbell… - Cancer discovery, 2018 - AACR
The Krüppel-like family of transcription factors plays critical roles in human development and
is associated with cancer pathogenesis. Krüppel-like factor 5 gene (KLF5) has been shown …