During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …

Background Developing a safe and immunogenic vaccine against Zika virus remains an
unmet medical need. We did two phase 1 studies that evaluated the safety and …

The emergence of ZIKV infection has prompted a global effort to develop safe and effective
vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine …

Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive
outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal …

Summary Background The Zika virus epidemic and associated congenital infections have
prompted rapid vaccine development. We assessed two new DNA vaccines expressing …

Abstract Background Although Zika virus (ZIKV) infection is typically self-limiting, other
associated complications such as congenital birth defects and the Guillain–Barré syndrome …

Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …

Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

The success of inactivated and live-attenuated vaccines has enhanced livestock
productivity, promoted food security, and attenuated the morbidity and mortality of several …