The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …
the activity of transposable elements (transposons). Transposons are mobile genetic …
Epithelial–immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis
GM Verstappen, S Pringle, H Bootsma… - Nature Reviews …, 2021 - nature.com
In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies
GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
Competition between two HUSH complexes orchestrates the immune response to retroelement invasion
The human silencing hub (HUSH) preserves genome integrity through the epigenetic
repression of invasive genetic elements. However, despite our understanding of HUSH as …
repression of invasive genetic elements. However, despite our understanding of HUSH as …
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
H Tunbak, R Enriquez-Gasca, CHC Tie… - Nature …, 2020 - nature.com
Abstract The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression
of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary …
of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary …
Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation
E Ochoa, P Ramirez, E Gonzalez, J De Mange… - Science …, 2023 - science.org
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature
of “tauopathies,” including Alzheimer's disease. Studies of human brain tissue and various …
of “tauopathies,” including Alzheimer's disease. Studies of human brain tissue and various …
New understanding of the relevant role of LINE-1 retrotransposition in human disease and immune modulation
X Zhang, R Zhang, J Yu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of
cancer accompanied by global chromosomal instability, genomic instability, and genetic …
cancer accompanied by global chromosomal instability, genomic instability, and genetic …
Repetitive elements in aging and neurodegeneration
KE Copley, J Shorter - Trends in Genetics, 2023 - cell.com
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
A balancing act: MDA5 in antiviral immunity and autoinflammation
AGD Junior, NG Sampaio, J Rehwinkel - Trends in microbiology, 2019 - cell.com
Induction of interferons during viral infection is mediated by cellular proteins that recognise
viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA …
viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA …