Research on mechanisms underlying the phenomenon of developmental programming of
health and disease has focused primarily on processes that are specific to cell types, organs …

The early-life environment, in particular maternal diet during pregnancy, influences a wide
range of organs and systems in adult offspring. Mounting evidence suggests that …

Insufficient oxygen supply (hypoxia) during fetal development leads to cardiac remodeling
and a predisposition to cardiovascular disease in later life. Previous work has shown …

The prevalence of overweight and obesity in reproductive-age adults is increasing
worldwide. While the effects of either paternal or maternal obesity on gamete health and …

The need to identify the most viable embryo following in vitro fertilization (IVF) was
established early in the history of human IVF. The stalwart of identifying the best embryos …

In brief Maternal obesity can impair metabolism in the embryo and the resulting offspring.
This study shows that metabolic disruptions through α-ketoglutarate may link altered …

Although it is not a well-established technology, oocyte cryopreservation is becoming
prevalent in assisted reproductive technologies in response to the growing demands of …

Background Previous studies have arguably associated poor embryo morphology with low
birth weight in singletons following single embryo transfer. However, the association …

Context: Complex cumulus cell-oocyte interactions govern energy utilization during oocyte
development. Objective: This study investigates the relationship of cumulus cell …

Betaine has been widely used in animal and human nutrition to promote muscle growth and
performance, yet it remains unknown whether maternal betaine supplementation during …