There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Leigh Syndrome (OMIM 256000) is a heterogeneous neurologic disorder due to damage in
mitochondrial energy production that usually starts in early childhood. The first description …

Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly
due to a lack of genotype calling and quality-control procedures. Developing an at-scale …

Abstract Lead (Pb 2+) is a non-essential metal with numerous industrial applications that
have led to its ubiquity in the environment. Thus, not only occupational-exposed individuals' …

Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial
energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting …

Chronic kidney disease of unknown etiology (CKDu) is an emerging global concern
affecting several agricultural communities in the Americas and South Asia. Environmental …

Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) is an
emerging pollutant transformed from 6-PPD. However, the effect of 6-PPDQ exposure on …

Amorphous silica nanoparticles (SNPs) are widely used in biomedical applications and
consumer products. Little is known, however, about their genotoxicity and potential to induce …

With the rapid development of nanotechnology, engineered nanomaterials (ENMs) are
widely used in various fields. This has exacerbated the environmental pollution and human …

An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …