The epigenomics of sarcoma
BA Nacev, KB Jones, AM Intlekofer, JSE Yu… - Nature Reviews …, 2020 - nature.com
Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …
Relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia: an overview of prevention and treatment
F Kreidieh, I Abou Dalle, N Moukalled… - International Journal of …, 2022 - Springer
Despite therapeutic progress in acute myeloid leukemia (AML), relapse post-allogeneic
hematopoietic stem cell transplantation (allo-HSCT) remains a major challenge. Here, we …
hematopoietic stem cell transplantation (allo-HSCT) remains a major challenge. Here, we …
Oncohistone mutations enhance chromatin remodeling and alter cell fates
JD Bagert, MM Mitchener, AL Patriotis, BE Dul… - Nature chemical …, 2021 - nature.com
Whole-genome sequencing data mining efforts have revealed numerous histone mutations
in a wide range of cancer types. These occur in all four core histones in both the tail and …
in a wide range of cancer types. These occur in all four core histones in both the tail and …
Cancer epigenetics: Past, present and future
JE Lee, MY Kim - Seminars in cancer biology, 2022 - Elsevier
Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …
suppressor genes. In the last 35 years, however, epigenetic changes have been …
H3. 3 G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in giant cell tumor of bone
Abstract Glycine 34-to-tryptophan (G34W) substitutions in H3. 3 arise in approximately 90%
of giant cell tumor of bone (GCT). Here, we show H3. 3 G34W is necessary for tumor …
of giant cell tumor of bone (GCT). Here, we show H3. 3 G34W is necessary for tumor …
Solid tumours hijack the histone variant network
Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …
Clinical implications of recurrent gene mutations in acute myeloid leukemia
J Yu, Y Li, D Zhang, D Wan, Z Jiang - Experimental hematology & …, 2020 - Springer
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy
characterized by recurrent gene mutations. Genomic heterogeneity, patients' individual …
characterized by recurrent gene mutations. Genomic heterogeneity, patients' individual …
Genomic characterization of relapsed acute myeloid leukemia reveals novel putative therapeutic targets
S Stratmann, SA Yones, M Mayrhofer… - Blood …, 2021 - ashpublications.org
Relapse is the leading cause of death of adult and pediatric patients with acute myeloid
leukemia (AML). Numerous studies have helped to elucidate the complex mutational …
leukemia (AML). Numerous studies have helped to elucidate the complex mutational …
Histone H3. 3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks
A Chaouch, J Berlandi, CCL Chen, F Frey, S Badini… - Molecular cell, 2021 - cell.com
Summary Histone H3. 3 lysine-to-methionine substitutions K27M and K36M impair the
deposition of opposing chromatin marks, H3K27me3/me2 and H3K36me3/me2. We show …
deposition of opposing chromatin marks, H3K27me3/me2 and H3K36me3/me2. We show …
Epigenetic activation of a RAS/MYC axis in H3. 3K27M-driven cancer
S Pajovic, R Siddaway, T Bridge, J Sheth… - Nature …, 2020 - nature.com
Abstract Histone H3 lysine 27 (H3K27M) mutations represent the canonical oncohistone,
occurring frequently in midline gliomas but also identified in haematopoietic malignancies …
occurring frequently in midline gliomas but also identified in haematopoietic malignancies …