Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

In this review, synthetic and mechanistic aspects of key methodologies that exploit C–C
single-bond cleavage of strained ring systems are highlighted. The focus is on transition …

Transition metal (TM)‐catalyzed difunctionalization of unactivated olefins with two carbon‐
based entities is a powerful method to construct complex molecular architectures rapidly …

The cleavage and reorganization of carbon− carbon bonds is an industrial key technology
for crude oil refining, carried out on a massive scale. In contrast, C− C bond cleavage …

The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a
useful strategy for preparing complex molecular structures. After oxidative addition of a …

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive
species are reviewed. A short introduction summarizes the basic reactivities of aryne …

A remaining challenge in the synthetic chemistry field is formation of all-carbon quaternary
centers, a feature found in many natural products, particularly in spirocycle systems. 1 …

We describe a synergistic utilization of cerium photocatalysis and photoinduced electron
transfer catalysis that enables an atom-and step-economical ring expansion of readily …

Transition‐metal‐mediated cleavage of C− C single bonds can enable entirely new
retrosynthetic disconnections in the total synthesis of natural products. Given that C− C bond …

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid
pinacol esters. The reaction is triggered by oxidative addition of an activated amide C–N …