The methylation effect in medicinal chemistry

EJ Barreiro, AE Kümmerle, CAM Fraga - Chemical reviews, 2011 - ACS Publications
The monovalent methyl group is derived from methane through the removal of a hydrogen
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …

Neuroinflammation and sympathetic overactivity: Mechanisms and implications in hypertension

D Haspula, MA Clark - Autonomic Neuroscience, 2018 - Elsevier
Essential hypertension is a multifactorial disorder with a strong genetic predisposition.
Although anti-hypertensive medications have drastically reduced cardiovascular diseases …

Spatially and temporally differentiated patterns of c‐fos expression in brainstem catecholamilriergic cell groups induced by cardiovascular challenges in the rat

RKW Chan, PE Sawchenko - Journal of Comparative …, 1994 - Wiley Online Library
Brainstem catecholaminergic neurons have been implicated as mediating adaptive
autonomic and neuroendocrine responses to cardiovascular challenges. To clarify the …

Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: afferent and efferent neuronal connections in relation to the baroreceptor reflex arc

M Palkovits, L Záborszky - Progress in brain research, 1977 - Elsevier
Publisher Summary In this chapter, the neuroanatomy of the baroreceptor reflex arc is
reviewed and relevant new data are presented. The baroreceptor reflex arc consists of a …

Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males

M Fornage, CI Amos, S Kardia, CF Sing, ST Turner… - Circulation, 1998 - Am Heart Assoc
Background—The renin-angiotensin system regulates blood pressure through its effects on
vascular tone, renal hemodynamics, and renal sodium and fluid balance. Methods and …

Sympathetic overactivity in hypertension and cardiovascular disease

M AJ, P LE, K MS, GI - Current vascular pharmacology, 2014 - benthamdirect.com
From the first description of its anatomy by T. Willis to the novel therapeutic manipulations, it
is unanimously recognized that the sympathetic nervous system (SNS) holds a crucial role in …

Tyrosine administration reduces blood pressure and enhances brain norepinephrine release in spontaneously hypertensive rats.

AF Sved, JD Fernstrom… - Proceedings of the …, 1979 - National Acad Sciences
Administration of L-tyrosine to normotensive or spontaneously hypertensive rats reduces
blood pressure. The effect is maximal within 2 hr of injection. In spontaneously hypertensive …

[图书][B] Pheochromocytoma

WM Manger, RWJ Gifford - 2012 - books.google.com
This monograph, which was more than five years in preparation, represents a very detailed
account of pheochromocytoma, a tumor that is almost invariably lethal if untreated. In …

Synaptic interaction of vagal afferents and catecholaminergic neurons in the rat nucleus tractus solitarius

KK Sumal, WW Blessing, TH Joh, DJ Reis, VM Pickel - Brain research, 1983 - Elsevier
Combined radioautography and immunocytochemistry were used to define the ultrastructure
and synaptic relations between vagal sensory afferents and catecholaminergic (CA) …

Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control

CA Ross, DA Ruggiero, TH Joh, DH Park, DJ Reis - Brain research, 1983 - Elsevier
Adrenaline-containing neurons of the rostral ventrolateral medulla (the C1 group) project
selectively to autonomic spinal neurons in rats. Stimulation of these neurons electrically or …