Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Somatostatin is an endogeneous cyclic tetradecapeptide hormone that exerts multiple
biological activities via five ubiquitously distributed receptor subtypes. Classified as a broad …

The endogenous cyclic tetradecapeptide SST14 was reported to stimulate all five
somatostatin receptors (SSTR1–5) for hormone release, neurotransmission, cell growth …

Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple
hormones such as growth hormone and thyroid-stimulating hormone, and thus are …

Ulcerative colitis and Crohn's disease are forms of inflammatory bowel disease whose
incidence and prevalence are increasing worldwide. These diseases lead to chronic …

The activity profile of many biologically relevant proteins and peptides often relies on a
precise 3D structural organization. In this context, disulfide bonds are natural covalent …

Somatostatin (SST) is a cyclic hormone-release inhibitory peptide that has high binding
affinity to all of its five SST receptors (SSTRs). SST negatively regulates cell proliferation and …

This review highlights developments in the field of ring-closing metathesis applied to the
synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba …

Designing peptidomimetic compounds to have a preorganized structure in solution is highly
nontrivial. To show how simulation-based approaches can help speed this process, we …

This review describes the recent advances in the microwave-assisted synthesis of 7-
membered and larger heterocyclic compounds. Several types of reaction for the cyclization …