Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Myelin is critical for the proper function of the nervous system and one of the most complex
cell–cell interactions of the body. Myelination allows for the rapid conduction of action …

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

The myelination of axons by glial cells was the last major step in the evolution of cells in the
vertebrate nervous system, and white-matter tracts are key to the architecture of the …

Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

Oligodendrocytes secrete vesicles into the extracellular space, where they might play a role
in neuron–glia communication. These exosomes are small vesicles with a diameter of 50 …

In addition to their role in providing myelin for rapid impulse propagation, the glia that
ensheath long axons are required for the maintenance of normal axon transport and long …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

The wrapping of multiple layers of myelin membrane sheets around an axon is of
fundamental importance for the function of the nervous system. In the central nervous system …