Dendrimers have unique molecular architectures and properties that make them attractive
materials for the development of nanomedicines. Key properties such as defined …

The transfer of nucleic acids (DNA or RNA) into living cells, that is, transfection, is a major
technique in current biochemistry and molecular biology. This process permits the selective …

Upon the aberrant activation of oncogenes, normal cells can enter the cellular senescence
program, a state of stable cell-cycle arrest, which represents an important barrier against …

Abstract Development of methods that allow an efficient expression of exogenous genes in
animals would provide tools for gene function studies, treatment of diseases and for …

Gene delivery using nonviral approaches has been extensively studied as a basic tool for
intracellular gene transfer and gene therapy. In the past, the primary focus has been on …

Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Development of an efficient method for introducing a therapeutic gene into target cells in
vivo is the key issue in treating genetic and acquired diseases by gene therapy. To this end …

Materials play a key role in several biomedical applications, and it is imperative that both the
materials and biological aspects are clearly understood for attaining a successful biological …

The transfer of genes into cells, both in vitro and in vivo, is critical for studying gene function
and conducting gene therapy. Methods that utilize viral and nonviral vectors, as well as …

In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …