Importance Preeclampsia is a hypertensive disorder of pregnancy that poses serious
maternal and infant health risks. Previous systematic reviews have established benefits of …

Preeclampsia is defined as hypertension arising after 20 weeks of gestational age with
proteinuria or other signs of end-organ damage and is an important cause of maternal and …

Background Preeclampsia and fetal growth restriction are major causes of perinatal death
and handicap in survivors. Randomized clinical trials have reported that the risk of …

The most important function of the placenta is the exchange of nutrients and oxygen
between a mother and her fetus. To establish a healthy functioning placenta, placentation …

Background: Preeclampsia is a leading cause of maternal and perinatal morbidity and
mortality. Purpose: To systematically review benefits and harms of low-dose aspirin for …

Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular
complications. The indications for the use of aspirin during pregnancy are, however, the …

OBJECTIVE: To estimate the effect of low-dose aspirin started in early pregnancy on the
incidence of preeclampsia and intrauterine growth restriction (IUGR). DATA SOURCES: A …

Background The optimum time for commencing antiplatelet therapy for the prevention of
preeclampsia and its complications is unclear. Aggregate data meta-analyses suggest that …

Background Pre‐eclampsia is associated with deficient intravascular production of
prostacyclin, a vasodilator, and excessive production of thromboxane, a vasoconstrictor and …

Objective To compare early vs late administration of low‐dose aspirin on the risk of perinatal
death and adverse perinatal outcome. Methods Databases were searched for keywords …