The Eurotiales is a relatively large order of Ascomycetes with members frequently having
positive and negative impact on human activities. Species within this order gain attention …

Covering: 1996–2022 Investigations over the last 2 decades have begun to reveal how
fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in …

A synthetic biology method based on heterologous biosynthesis coupled with genome
mining is a promising approach for increasing the opportunities to rationally access natural …

Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Self‐resistance genes are employed by many microbial producers of bioactive natural
products to avoid self‐harm. Herein, we describe a unique strategy for self‐resistance …

By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-
terminal adenylation–thiolation didomain, which catalyzes the formation of naringenin …

Presented herein is a synthetic biological method using genome mining and heterologous
expression systems that provides access to natural products with desirable structural …

Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a
diterpene connected to a pyrone, some of which show potent bioactivity. Through genome …

Highlights•Pathogenic fungi produce secondary metabolites (SMs) to control the host and its
environment.•Functional genomics facilitates identification of new SM effectors.•Population …