Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

Preservation of aerobic fitness and skeletal muscle strength through exercise training can
ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated …

Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

PGC-1α is a transcriptional coactivator induced by exercise that gives muscle many of the
best known adaptations to endurance-type exercise but has no effects on muscle strength or …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in
cells. Recent work highlighted that PGC1α can also modulate the composition and functions …

High‐intensity interval training (HIT) induces skeletal muscle metabolic and performance
adaptations that resemble traditional endurance training despite a low total exercise volume …

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie
muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue
(VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM) …