Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Perinatal brain injury and inflammation: lessons from experimental murine models

A Leavy, EM Jimenez Mateos - Cells, 2020 - mdpi.com
Perinatal brain injury or neonatal encephalopathy (NE) is a state of disturbed neurological
function in neonates, caused by a number of different aetiologies. The most prominent cause …

DNA damage in organs of mice treated acutely with patulin, a known mycotoxin

FT de Melo, IM de Oliveira, S Greggio… - Food and Chemical …, 2012 - Elsevier
Patulin, a known mycotoxin, is considered a significant contaminant in apples, apple-derived
products and feeds. This study investigated the genotoxic effects of patulin in multiple …

Whether short peptides are good candidates for future neuroprotective therapeutics?

R Perlikowska - Peptides, 2021 - Elsevier
Neurodegenerative diseases are a broad group of largely debilitating, and ultimately
terminal conditions resulting in progressive degeneration of different brain regions. The …

Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus

I Ullah, H Badshah, MI Naseer, HY Lee… - Neuromolecular …, 2015 - Springer
Epilepsy is a common neurological disorder that leads to neuronal excitability and provoke
various forms of cellular reorganization in the brain. In this study, we investigate the anti …

Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases

H Sudo, PW Baas - Human molecular genetics, 2011 - academic.oup.com
It is commonly stated that microtubules gradually disintegrate as tau becomes dissociated
from them in tauopathies such as Alzheimer's disease. However, there has been no …

Davunetide: peptide therapeutic in neurological disorders

I Magen, I Gozes - Current medicinal chemistry, 2014 - ingentaconnect.com
This review focuses on the therapeutic effects and mechanisms of action of NAP
(davunetide), an eight amino acid snippet derived from activity-dependent neuroprotective …

Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain

NK Sharma, NK Sethy, RN Meena, G Ilavazhagan… - Peptides, 2011 - Elsevier
Hypobaric hypoxia is a socio-economic problem affecting cognitive, memory and behavior
functions. Severe oxidative stress caused by hypobaric hypoxia adversely affects brain …

Gender-dependent changes in physical development, BDNF content and GSH redox system in a model of acute neonatal hypoxia in rats

IA Sukhanova, EA Sebentsova, DD Khukhareva… - Behavioural Brain …, 2018 - Elsevier
Perinatal hypoxia–ischaemia is one of the leading factors that negatively influence the
development of the central nervous system. Our aim was to investigate the effects of sex on …

Early-life N-arachidonoyl-dopamine exposure increases antioxidant capacity of the brain tissues and reduces functional deficits after neonatal hypoxia in rats

IA Sukhanova, EA Sebentsova, DD Khukhareva… - International Journal of …, 2019 - Elsevier
Perinatal hypoxia-ischemia is one of the most common causes of perinatal brain injury and
subsequent neurological disorders in children. The aim of this work was to evaluate the …